High cerebrospinal amyloid-β 42 is associated with normal cognition in individuals with brain amyloidosis

Plasma amyloid β 42/40 ratios as biomarkers for amyloid β cerebral deposition in cognitively normal individuals

INTRODUCTION Plasma amyloid β (Aβ) peptides have been previously studied as candidate biomarkers to increase recruitment efficiency in secondary prevention clinical trials for Alzheimer's disease. METHODS Free and total Aβ42/40 plasma ratios (FP42/40 and TP42/40, respectively) were determined using ABtest assays in cognitively normal subjects from the Australian Imaging, Biomarker and Lifesty...

Amyloid β in hereditary cerebral hemorrhage with amyloidosis-Dutch type.

Hereditary cerebral hemorrhage with amyloidosis - Dutch type is an autosomal dominant hereditary disease caused by a point mutation in the amyloid precursor protein gene on chromosome 21. The mutation causes an amino acid substitution at codon 693 (E22Q), the 'Dutch mutation'. Amyloid β, the product after cleavage of the amyloid precursor protein, is secreted into the extracellular space. The D...

Correlation of specific amyloid-β oligomers with tau in cerebrospinal fluid from cognitively normal older adults.

IMPORTANCE To improve the ability to develop treatments that prevent incipient Alzheimer disease (AD) from progressing to overt AD, it is important to understand the molecular basis of the earliest pathophysiological abnormalities and to determine how amyloid-β (Aβ) is involved very early in its pathogenesis. OBJECTIVE To investigate 2 specific Aβ oligomers, Aβ trimers and Aβ*56, in human cer...

Serum Level of Soluble CD226 Receptor in Healthy Individuals is Highly Variable and Associated with Age

Study of Cerebrospinal Fluid Tissue Transglutaminase , T - TAU , Amyloid Β 42 in Alzheimer ’ s Disease

Biochemical markers for Alzheimer disease would be of great value, especially to help in early diagnosis of the disease. The current study has focused on three candidates that have been suggested to be indulged in the pathogenesis of Alzheimer’ disease (AD): Tissue transglutaminase (tTG) activity, β-amyloid42 (Aβ 42) and total T-tau (T-tau). The study included 15 patients with probable AD, 15 p...